CRISPR Cas9 Ver01 Patent Landscape Analytics

How to Use this report:

• Use the Table of Contents below to navigate to specific sections by clicking on the headings.

• The HTML version of this report provides interactive figures and tables, with mouse-over, zoomable data display, and searchable, sortable tables. This provides the user with the capability to further explore the landscaping results.

• This report is updated on an as-needed basis.

Table of Contents:

• Overview

• Summary of the Fundamental CRISPR Patent Documents

• Summary of All Patent Documents in Ungrouped Domain Collection

• Summary of the Top Current Assignee Regions

• Simple Legal Status of Grouped Patent Documents in Domain Collection

• Applications and Granted Patents Timeline

• Top 100 Inventors

• Top 100 Standardized Current Assignees

• Top 50 Most Cited Patent Documents

• Technology Classification Code Analysis

• Landscape Diagram Image Analysis

Overview:

The PatSnap Connected Innovation Intelligence platform was used to execute this patent landscape analysis. PatSnap’s semantic search capability was used to generate the domain collection by executing 28 separate semantic queries using each of the documents named in the February 28th USPTO PTAB Interference decision. Each semantic query yields up to 1,000 of the most semantically similar patent documents. These queries were first executed as two subdomains and stored as separate workspaces within PatSnap. The first was for the 14 documents from the Berkeley group, which consists of the University of California Berkeley, the University of Vienna, and scientist Emmanuelle Charpentier, who was formerly associated with the University of Vienna, collectively referred to as “CVC” in the Interference decision. The second subdomain consists of the 14 documents from the Broad Institute group, consisting of The Broad Institute, the Massachusetts Institute of Technology, and Harvard University, collectively referred to as “Broad” in the Interference decision. These subdomains were then combined into a single workspace so that the results of the 28 semantic queries were aggregated into a final domain collection for analysis. As the query results and subdomains are combined into a single workspace, duplicate patent documents are deleted automatically by the PatSnap tool. For the 14 patent documents assigned to the CVC group, this process resulted in a subdomain collection of 1,382 patent documents consisting of 373 simple patent families. For the 14 patent documents assigned to the Broad Institute group, this process resulted in a subdomain of 2,967 patent documents consisting of 757 simple families. Combing the two subdomains to produce the final domain collection resulted in a workspace with 3,455 patent documents consisting of 859 simple patent families. The patent document landscaping analysis was performed on this workspace.

• This is a summary table of the fundamental CRISPR patent documents that have been used as seeds in semantic queries to create the domain collection.
• These are the 28 patent documents named in the February 28, 2022 USPTO PTAB Interference Proceeding.
• Click on column headings to sort.
• Use the Search boxes to search on any column.

• This is a summary table of the all the patent documents in the domain collection. The domain collection consists of 3,455 patent documents consisting of 859 simple patent families.
• Many of these documents could be duplicates of the same patent application or granted patent in different countries.
• Click on column headings to sort.
• Use the Search boxes to search on any column.

• This is a summary table of the top current assignee countries and tabulates the countries of assignees across all grouped patent families in the domain collection.
• This table is designed to show the geographic concentrations of the owners of the intellectual property.
• For the CRISPR domain collection this is indicating that the assignees of the fundamental IP largely reside in the United States, which is not unexpected given that the initial patent filings in this IP sector were by the Berkeley group and the Broad Institute group.

• This is a summary table of the simple legal status of the patent documents in the domain collection and presents the data corresponding to the filing stages of the documents.
• The PCT (Patent Cooperation Treaty) classifications refer to the initial filing stages of internationally designated patent applications.
• The Pending classification refers to applications that are pending in national stage examinations.
• Active classification refers to granted patents.
• This chart is often useful in providing insight into the maturity of an IP sector.
• For the CRISPR domain collection, it is indicating that it’s still early in the evolution of this IP sector as 45% of the patent families are still in pending stage and only approximately 20% have been granted.

• The applications and granted patents timeline provides a concise view of the historic trends of patenting activity embodied in the domain collection.
• The chart shows the number of granted patents resulting from applications filed in the same year.
• This is helpful for understanding the application filing rate as well as the grant rate for the IP sector. The application filing rate can be an indicator of the IP competitive landscape and the grant rate can an indicator of the approval environment.
• Also note that the most recent data (the most recent ~18-24 months) is likely only partial data, as there are publishing delays and sometimes long pendency times (time between application and grant approval) associated with various patent jurisdictions.
• For the CRISPR domain collection the increasing application numbers and the decreasing grant rate both indicate an increasingly competitive environment with more applications being filed and fewer granted patents being allowed on a percentage basis. The current grant rate for this IP sector is approximately 10%.

• This shows the top 100 inventors for the CRISPR domain collection and essentially lists the individuals who are the top intellectual property experts.
• For the CRISPR domain collection this list is led by individuals associated with the Broad Institute group and the Berkeley group.
• Click on column headings to sort.
• Use the Search boxes to search on any column.

• This shows the top 100 standardized current assignees. The standardization of assignees in this list is a process within PatSnap where assignees and tabulations of patent documents are aggregated to account for M&A transactions and situations where an assignee is a division of a parent corporation.
• Click on column headings to sort.
• Use the Search boxes to search on any column.

• This shows the most cited patent documents across all the documents in the domain collection and can help identify foundational prior art and important patent references as well as additional IP competitors (assignees) in the sector.
• A cited patent document is typically a patent application or granted patent that is considered significant (prior art, or in some way relevant) to the patent application that cites it.
• The table below thus represents the list of the top 50 most cited patent document references on granted patents and patent applications in the CRISPR domain collection.
• Click on column headings to sort.
• Use the Search boxes to search on any column.

• Patent document technology classification codes are often utilized to gain insight into the technology applied in an IP sector or domain collection by analyzing the patent document information, the assigned class codes, and the description of those class codes.
• Classification codes are assigned to every patent document to categorize the inventive ideas. Patent documents can be assigned multiple classification codes representing each potentially different inventive idea embodied in the patent filing.
• The tables below show the break-down of the technology classification codes as applied to the patent documents of the top assignees. The first table shows the top five classification codes applied to all patent documents in the domain collection as well as the corresponding descriptions. The second table then shows the tabulation of the top five class codes as applied to the patent documents of the top 10 assignees.
• In a general sense this shows the broader areas of focus for those top assignees.

• Patent landscape diagramming is a versatile technique that can be used to visualize and explore a patent document domain collection.
• The main landscape diagram is generated via natural language processing (NPL) and semantically similar text clustering of the patent documents in the domain collection. A topographical diagram is generated using all the documents of the domain collection with topographical peaks representing higher concentrations of patent documents and troughs representing areas with lower concentrations or no patent documents at all. Textbox callouts are then generated for the higher concentrations and significantly differentiated text clusters.
• The diagram below shows the topographical landscape diagram created from the 3,455 ungrouped patent documents of the CRISPR domain collection. Textbox callouts have been automatically added for the NLP-derived clusters of patent documents. Red and yellow dots have been added to the diagram that represent the patent documents assigned to the entities of the Berkeley group (yellow dots) and the Broad Institute group (red dots). This visualization shows how the semantic analysis algorithm has differentiated the focus areas of the two research organizations, with the Berkeley group patent documents mostly in the upper-left corner of the diagram and the Broad Institute group documents in the lower-left corner.